Route 22 eastbound and westbound is closed in Lewistown due to a stuck tractor-trailer.
The highway is closed between its intersections with Route 522 and Twenty-Eighth Division Highway.
PennDOT spokeswoman Dawn Roussey said the truck with an oversized load is stuck within the barriers.
Detours are in place for both directions.
Roussey said Route 22 is expected to reopen by noon.